Of course you can leave your puppy at home! You can't take your puppy to school or work, or to the hospital, or a movie!
However, there are special preparations and care that you must take when you leave your pup alone.
The very best way to ensure that he is safe is to use a crate. Some people have a different place set aside in the house such as a room or area free from any dangers. Also, you will need to provide water and other comforts like a blanket or a bed and air conditioning and a place for elimination.
There is a time limit too, depending on the age of the pup. A very young pup should be checked on about every 4 hours. If your Boston is older, he could probably go for 8 hours.